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Article

Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease.

PloS one - 24 Feb 2011

Hu Xiaolan, Pickering Eve, Liu Yingxue Cathy, Hall Stephanie, Fournier Helene, Katz Elyse, Dechairo Bryan, John Sally, Van Eerdewegh Paul, Soares Holly

Abstract excerpt

Recent GWAS studies focused on uncovering novel genetic loci related to AD have revealed associations with variants near CLU, CR1, PICALM and BIN1. In this study, we conducted a genome-wide association study in an independent set of 1034 cases and 1186 controls using the Illumina genotyping platforms. By coupling our data with available GWAS datasets from the ADNI and GenADA, we replicated the original...

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Source

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Identifiers

PMID: 21390209
DOI: 10.1371/journal.pone.0016616
PMCID: PMC3044719

Genes

BIN1
PICALM
CLU
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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