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Article

Genetic association of BIN1 and GAB2 in Alzheimer's disease: A meta-analysis and systematic review.

Geriatrics & gerontology international - 1 Feb 2021

Hao Xiaoyan, Wang Aijun, Li Chong, Shao Lufei, Li Yi, Yang Ping

Abstract excerpt

AIM: Heredity plays an important role in the pathogenesis of Alzheimer's disease (AD) especially for single-nucleotide polymorphism (SNPs) of susceptible genes, which is one of the significant factors in the pathogenesis of AD. The SNPs of BIN1 rs744373, BIN1 rs7561528 and GAB2 rs2373115 are associated with AD in Asian and white people. METHODS: We included 34 studies with a total of 38 291 patients with AD and...

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PMID: 33331110
DOI: 10.1111/ggi.14109
PMCID: PMC7898709

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