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Article

Complex genetic interactions affect susceptibility to Alzheimer's disease risk in the BIN1 and MS4A6A loci.

GeroScience - 1 Jun 2025

Nazarian Alireza, Morado Marissa, Kulminski Alexander M

Abstract excerpt

Genetics is the second strongest risk factor for Alzheimer's disease (AD) after age. More than 70 loci have been implicated in AD susceptibility so far, and the genetic architecture of AD entails both additive and nonadditive contributions from these loci. To better understand nonadditive impact of single-nucleotide polymorphisms (SNPs) on AD risk, we examined individual, joint, and interacting (SNPxSNP) effects...

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Identifiers

PMID: 39751715
DOI: 10.1007/s11357-024-01477-6
PMCID: PMC12181559

Genes

BIN1
MS4A6A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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