Article
Common variants at Bin1 are associated with sporadic Alzheimer's disease in the Han Chinese population.
Psychiatric genetics - 1 Feb 2015
Li Hong-Lei, Yang Ping, Liu Zhi-Jun, Sun Yi-Min, Lu Shen-Ji, Tao Qing-Qing, Guo Qi-Hao, Wu Zhi-Ying
Abstract excerpt
OBJECTIVES: Recent genome-wide association studies identified bridging integrator 1 (Bin1) to be associated with sporadic Alzheimer's disease (SAD). To clarify the relevance of Bin1 as a genetic determinant of AD, we analyzed its association in a Han Chinese population from the South East part of mainland China. METHODS: This study investigated 427 SAD patients and 451 unrelated age-matched and sex-matched...
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