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Article

Bridging Integrator 1 (BIN1) Genotypes Mediate Alzheimer's Disease Risk by Altering Neuronal Degeneration.

Journal of Alzheimer's disease : JAD - 15 Mar 2016

Wang Hui-Fu, Wan Yu, Hao Xiao-Ke, Cao Lei, Zhu Xi-Chen, Jiang Teng, Tan Meng-Shan, Tan Lin, Zhang Dao-Qiang, Tan Lan, Yu Jin-Tai

Abstract excerpt

BACKGROUND: Bridging integrator 1 (BIN1) has been identified as one of the most associated loci for Alzheimer's disease (AD), and recently was reported to modulate tau pathology to mediate AD in vitro. However, the effects of BIN1 on the AD related biomarkers in AD continuum were not specifically assessed. OBJECTIVE: We explored the effects of BIN1 loci on AD specific biomarkers (CSF proteins, brain structures,...

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Identifiers

PMID: 27003210
DOI: 10.3233/JAD-150972

Genes

BIN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Bridging Integrator 1 (BIN1) Genotypes Mediate Alzheimer's Disease Risk by Altering Neuronal Degeneration.PMID 27003210Read ↗

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New Insights on Bridging Integrator 1 Protein Isoforms as a Risk Increasing Gene in Alzheimer’s DiseaseSemantic proximity Read ↗

Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease.Semantic proximity Read ↗

The bridging integrator 1 Gene rs7561528 polymorphism contributes to Alzheimer's disease susceptibility in East Asian and Caucasian populations.Semantic proximity Read ↗

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