Article
Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network.
Alzheimer's research & therapy - 25 Jul 2018
Karch Celeste M, Hernández Damián, Wang Jen-Chyong, Marsh Jacob, Hewitt Alex W, Hsu Simon, Norton Joanne, Levitch Denise, Donahue Tamara, Sigurdson Wendy, Ghetti Bernardino, Farlow Martin, Chhatwal Jasmeer, Berman Sarah, Cruchaga Carlos, Morris John C, Bateman Randall J, Pébay Alice, Goate Alison M
Abstract excerpt
BACKGROUND: Mutations in amyloid precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2) cause autosomal dominant forms of Alzheimer disease (ADAD). More than 280 pathogenic mutations have been reported in APP, PSEN1, and PSEN2. However, understanding of the basic biological mechanisms that drive the disease are limited. The Dominantly Inherited Alzheimer Network (DIAN) is an international...
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