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Article

Characteristics and Transcriptomic Analysis of Cholinergic Neurons Derived from Induced Pluripotent Stem Cells with APP Mutation in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2024

Sun Wenxian, Chen Yufei, Yang Yuting, Wang Pin, Gong Jin, Han Xiaodong, Xu Chang, Luan Heya, Li Shaoqi, Li Ruina, Wen Boye, Lv Sirong, Wei Cuibai

Abstract excerpt

Background: The cholinergic hypothesis is one of the main theories that describe the pathogenesis of Alzheimer's disease (AD). Cholinergic neurons degenerate early and are severely damaged in AD. Despite extensive research, the causes of cholinergic neuron damage and the underlying molecular changes remain unclear. Objective: This study aimed to explore the characteristics and transcriptomic changes in...

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Source

Identifiers

PMID: 39213067
DOI: 10.3233/JAD-240299

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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