Article

Cell growth and mitochondrial anomalies in induced pluripotent stem cells with Presenilin 1 mutation

2024-06-06

Abstract excerpt

<title>Abstract</title> <p>Presenilin 1 (PSEN1) is the most frequently mutated gene in early-onset sporadic and familial Alzheimer’s disease (FAD). The PSEN1 complex displays gamma-secretase activity and promotes cleavage of the C99-terminal fragment of the Amyloid Precursor Protein (APP) into the Aβ42 peptide. PSEN1 is also involved in vesicle transport across ER and mitochondria in so called mitochondria associ...

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Literature Corpus work: 1b24e1f4-fe73-5518-a28c-7cc1a3a51ef7
DOI: 10.21203/rs.3.rs-4415469/v1

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