Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neurodegeneration in a dish: advancing human stem-cell-based models of Alzheimer's disease.

Current opinion in neurobiology - 1 Apr 2020

Klimmt Julien, Dannert Angelika, Paquet Dominik

Abstract excerpt

Induced pluripotent stem-cell-based models enable investigation of pathomechanisms in disease-relevant human brain cell types and therefore offer great potential for mechanistic and translational studies on neurodegenerative disorders, such as Alzheimer's disease (AD). While current AD models allow analysis of early disease phenotypes including Aβ accumulation and Tau hyperphosphorylation, they still fail to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Alzheimer Disease
Share to Induced Pluripotent Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to tau Proteins

Source

Identifiers

PMID: 32112992
DOI: 10.1016/j.conb.2020.01.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neurodegeneration in a dish: advancing human stem-cell-based models of Alzheimer's disease.PMID 32112992Read ↗

Alzheimer's disease in a dish: promises and challenges of human stem cell models.Semantic proximity Read ↗

Reprogramming the Brain—iPSC Models Illuminating the Pathogenesis and Treatment of Alzheimer’s Disease and Other DementiasSemantic proximity Read ↗

Stem Cell Therapies in Alzheimer’s Disease: Applications for Disease ModelingSemantic proximity Read ↗

Human-induced pluripotent stem cells: potential for neurodegenerative diseases.Semantic proximity Read ↗

Dissecting the complexities of Alzheimer disease with in vitro models of the human brain.Semantic proximity Read ↗

Human iPSC-Derived Neurons as A Platform for Deciphering the Mechanisms behind Brain AgingSemantic proximity Read ↗

Generation of an Alzheimer’s Disease Model Derived from Induced Pluripotent Stem Cells with an APP Gene MutationSemantic proximity Read ↗

Human Induced Pluripotent Stem Cells and the Modelling of Alzheimer’s Disease: The Human Brain Outside the DishSemantic proximity Read ↗

Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells?Semantic proximity Read ↗

Alzheimer's Disease Modeling: Ups, Downs, and Perspectives for Human Induced Pluripotent Stem CellsSemantic proximity Read ↗

A human embryonic stem cell model of Aβ-dependent chronic progressive neurodegenerationSemantic proximity Read ↗

Human stem cell models of neurodegeneration: a novel approach to study mechanisms of disease development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.