Article

Orexin 2 receptor Crosstalk with GLP1 receptor reveals dual therapy for improvement of Sleep deprivation-induced obesity: An Integrated Network Pharmacology, Molecular Docking and Molecular Dynamics Simulation approach

2025-12-11

Abstract excerpt

<title>Abstract</title> <p>The Glucagon-Like Peptide-1 Receptor (GLP1R) and the Hypocretin/Orexin Receptor Type 2 (HCRTR2) are critical G protein-coupled receptors that govern metabolism and neuroendocrine function. Clinical observations suggest a functional overlap, particularly in the regulation of appetite, energy homeostasis, and sleep/wake cycles. Sleep disturbance profoundly disrupts neuroendocrine and meta...

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Literature Corpus work: 5645d751-7333-5169-bb30-007a6e4b8b3a
DOI: 10.21203/rs.3.rs-8183695/v1

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