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Article

Exploring the molecular structures that confer ligand selectivity for galanin type II and III receptors.

PloS one - 1 Jan 2020

Lee Yoo-Na, Reyes-Alcaraz Arfaxad, Yun Seongsik, Lee Cheol Soon, Hwang Jong-Ik, Seong Jae Young

Abstract excerpt

Galanin receptors (GALRs) belong to the superfamily of G-protein coupled receptors. The three GALR subtypes (GALR1, GALR2, and GALR3) are activated by their endogenous ligands: spexin (SPX) and galanin (GAL). The synthetic SPX-based GALR2-specific agonist, SG2A, plays a dual role in the regulation of appetite and depression-like behaviors. Little is known, however, about the molecular interaction between GALR2...

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Identifiers

PMID: 32231393
DOI: 10.1371/journal.pone.0230872
PMCID: PMC7108740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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