Artificial Intelligence Uncovers Evolutionarily Conserved Intracellular Allosteric Modulators of GPCR-Gα Interface

Abstract excerpt

<title>Abstract</title> <p>Traditionally, the exogenous allosteric modulators of G protein-coupled receptors (GPCRs) have been extensively investigated due to their pharmacological significance. However, to date, only a handful of endogenous intracellular allosteric modulators are known, that too with inconclusive binding information and their associated phenotypes. This limitation primarily stems from the non-av...

Topics

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• Databases, Protein
• Eukaryotic Cells
• GTP-Binding Proteins
• Molecular Sequence Annotation
• Protein Conformation, alpha-Helical
• Protein Conformation, beta-Strand
• Protein Interaction Domains and Motifs
• Small Molecule Libraries

Identifiers and source

Literature Corpus work

bac68a7f-2a79-515d-8e60-95e05e02cbd1

DOI

10.21203/rs.3.rs-2611000/v1