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Molecular dynamics-guided optimization of BGM0504 enhances dual-target agonism for combating diabetes and obesity

19 Jul 2024

Abstract excerpt

The dual activation of glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) has emerged as a promising therapeutic strategy for managing type 2 diabetes and obesity. Tirzepatide, a dual agonist peptide, has exhibited superior clinical efficacy in glycemic and weight control compared to selective GLP-1R agonists. Nevertheless, the structural basis of...

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PMID: 39030216
DOI: 10.1038/s41598-024-66998-8

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