Article

Orphan G protein-coupled receptor, GPR37L1: pharmacological toolbox empty once again

2020-09-11

Abstract excerpt

Orphan G protein-coupled receptors (GPCRs) are largely intractable therapeutic targets, owing to the lack of chemical tools for exploring their pharmacology. The discovery of such tools, however, is hampered by a number of unknowns, such as effector coupling and appropriate positive controls. In our 2017 Nature Chemical Biology paper 1 , we developed a computational chemical tool discovery approach called GPCR Co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 69ff74f8-fbdb-5ecb-85f8-025d8a8558ab
DOI: 10.1101/2020.09.11.290486

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Orphan G protein-coupled receptor, GPR37L1: pharmacological toolbox empty once againDOI 10.1101/2020.09.11.290486Read

Key aspects of modern GPCR drug discoverySemantic proximity Read

<i>In vitro</i> profiling of orphan G protein coupled receptor (GPCR) constitutive activitySemantic proximity Read

International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands.Semantic proximity Read

G protein-coupled receptors: dominant players in cell-cell communication.Semantic proximity Read

Focus issue: Cracking the G protein-coupled receptor code.Semantic proximity Read

Direct interrogation of context-dependent GPCR activity with a universal biosensor platformSemantic proximity Read

The G protein database, GproteinDb.Semantic proximity Read

GPCRs: The most promiscuous druggable receptor of the mankindSemantic proximity Read

Modeling and Deorphanization of Orphan GPCRs.Semantic proximity Read

The Identification of Ligands at Orphan G-Protein Coupled ReceptorsSemantic proximity Read

Advances in the molecular level understanding of G-protein coupled receptor.Semantic proximity Read

Expanding horizons for receptors coupled to G proteins: diversity and disease.Semantic proximity Read