Article

Structural dynamics underlying agonist activation of a GLP-1R-Gs precoupled complex

2026-08-04

Abstract excerpt

G-protein-coupled receptors (GPCRs) act as allosteric transmembrane signalling machines, generating distinct cellular responses depending on the conformational states induced by ligand binding. The glucagon-like peptide-1 receptor (GLP-1R), a class B GPCR central to insulin secretion and body-weight regulation, is a key therapeutic target for obesity-associated metabolic disease. Here, we used hydrogen–deuterium e...

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Literature Corpus work: 6d73f265-8218-5179-87b9-2cafddce52c7
DOI: 10.64898/2026.08.03.742488

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