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The current state of GPCR ‐based drug discovery to treat metabolic disease

3 Feb 2018

Abstract excerpt

One approach of modern drug discovery is to identify agents that enhance or diminish signal transduction cascades in various cell types and tissues by modulating the activity of GPCRs. This strategy has resulted in the development of new medicines to treat many conditions, including cardiovascular disease, psychiatric disorders, HIV/AIDS, certain forms of cancer and Type 2 diabetes mellitus (T2DM). These...

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PMID: 29394497
DOI: 10.1111/bph.14157

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