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State-dependent photocrosslinking unveiled the role of intersubunit interfaces on Ca 2+ activating mechanisms of the BK channel

2022-12-18

Abstract excerpt

BK channels are high-conductance potassium channels that are activated by voltage and Ca 2+ . The pore-forming α-subunits form homotetramers including a membrane-spanning domain and a cytosolic domain with a tandem of RCK-like domains (RCK1 and RCK2) per subunit. The eight RCKs compose high affinity Ca2+-binding sites that drive channel activation. Full-length Cryo-EM structures revealed intersubunit interactions...

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Literature Corpus work: 562e8dd2-b22f-53db-b076-ca177fc6c1b9
DOI: 10.1101/2022.12.15.520511

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State-dependent photocrosslinking unveiled the role of intersubunit interfaces on Ca 2+ activating mechanisms of the BK channelDOI 10.1101/2022.12.15.520511Read

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