Article

Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease

2024-08-06

Abstract excerpt

TASK-1 and TASK-3 are pH-sensitive Two-Pore Domain (K2P/ KCNK ) K + channels. Their functional roles make them promising targets for the treatment of multiple disorders including sleep apnea, pain and atrial fibrillation. Rare genetic mutations in these channels are also associated with neurodevelopmental and hypertensive disorders. A recent crystal structure of TASK-1 revealed a lower ‘X-gate’ that is a hotspot...

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Literature Corpus work: 272fa1b1-b3fe-5a69-b950-132d23bec0e6
DOI: 10.1101/2024.08.05.606641

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