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Article

Determinants of pH sensing in the two-pore domain K(+) channels TASK-1 and -2.

Pflugers Archiv : European journal of physiology - 1 Feb 2003

Morton Michael J, O'Connell Anthony D, Sivaprasadarao Asipu, Hunter Malcolm

Abstract excerpt

TASK-1 and -2 are members of the two-pore domain potassium (K(+)) channel family and are sensitive to changes in extracellular pH. The effects of mutating charged, extracellular-facing residues in TASK-1 and -2 were studied in Xenopusoocytes by two-electrode voltage clamp. Hydrogen ion block was independent of voltage with K(d) values of 149+/-17.9 nM [H(+)] ( n=6) and 5.76+/-1.23 nM [H(+)] ( n=7) for TASK-1 and...

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Identifiers

PMID: 12634929
DOI: 10.1007/s00424-002-0901-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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