Article

5-azacytosine induces cytotoxicity via 5-methylcytosine depletion on chromatin-associated RNA in leukemia

2025-06-27

Abstract excerpt

<h4>SUMMARY</h4> 5-azacytidine (5-azaC) is a DNA hypomethylating agent clinically used to improve outcomes in myeloid malignancies. However, 5-azaC treatment causes gene dysregulation inconsistent with DNA hypomethylation changes, suggesting alternative mechanisms of action by 5-azaC. As a ribonucleoside analogue, 5-azaC is more readily incorporated into nascent RNA. Here, we demonstrate that RNA 5-methylcytosine...

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Literature Corpus work: ab1397d8-a9a7-5061-ac7d-c605b3439f87
DOI: 10.1101/2025.06.24.661348

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