Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

5-Azacytidine and decitabine induce C > G transversions in both murine and human cells.

Leukemia - 1 Sept 2025

Bertoli Ryan, Cao Dengchao, Tuckey Olivia, Gammell Susannah, Wokasch Anthony, Chung Yang Jo, Foulks Jason M, Aplan Peter D

Abstract excerpt

5-Azacytidine (5AZA) is a DNA methyltransferase inhibitor (DNMTi) used clinically to treat myelodysplastic neoplasm (MDS), and is used off-label for a number of malignancies including acute myeloid leukemia. This cytidine analog depletes intracellular DNMT1, and it has been hypothesized that DNMT1 depletion leads to hypomethylation and de-repression of methylated tumor suppressor genes. We used a pre-clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimetabolites, Antineoplastic
Share to Azacitidine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Decitabine

Share to DNA Methylation

Share to Mutation

Share to Myelodysplastic Syndromes

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Open in PubMed Open full text

Identifiers

PMID: 40681875
DOI: 10.1038/s41375-025-02670-y
PMCID: PMC12380594

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

5-Azacytidine and decitabine induce C > G transversions in both murine and human cells.PMID 40681875Read ↗

The DNA Methyltransferase Inhibitor 5-Aza-4′-thio-2′-Deoxycytidine Induces C>G Transversions and Acute Lymphoid Leukemia DevelopmentSemantic proximity Read ↗

5-Aza-4’-thio-2’-deoxycytidine induces C>G transversions in a specific trinucleotide context and leads to acute lymphoid leukemiaSemantic proximity Read ↗

Demethylating Agents in the Treatment of CancerSemantic proximity Read ↗

Cytosine modifications in myeloid malignancies.Semantic proximity Read ↗

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemiaSemantic proximity Read ↗

An update on the safety and efficacy of decitabine in the treatment of myelodysplastic syndromesSemantic proximity Read ↗

Discovery of chromatin-based determinants of azacytidine and decitabine anti-cancer activitySemantic proximity Read ↗

DNMT inhibitors increase methylation at subset of CpGs in colon, bladder, lymphoma, breast, and ovarian, cancer genomeSemantic proximity Read ↗

Demethylating agents in myeloid malignanciesSemantic proximity Read ↗

Clinical development of demethylating agents in hematologySemantic proximity Read ↗

Comprehensive comparison between azacytidine and decitabine treatment in an acute myeloid leukemia cell lineSemantic proximity Read ↗

MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.