Article

Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1-mediated cell-intrinsic resistance

2024-05-21

Abstract excerpt

<h4>SUMMARY</h4> While nucleoside DNA methyltransferase inhibitors (DNMTi) such as decitabine and azacitidine are effective in treating myelodysplatic syndrome (MDS)/leukemia, they have had limited utility for the majority of other cancers. Through a chemical library screen, we identified that triptolide, a diterpenoid epoxide from Tripterygium wilfordii , or analogs significantly augmented the epigenetic and an...

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Literature Corpus work: e71f2200-4251-544a-bd1e-76f408e8f80b
DOI: 10.1101/2024.05.19.594134

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