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DNA methylation aberrancies as a guide for surveillance and treatment of human cancers

30 Mar 2017

Abstract excerpt

DNA methylation aberrancies are hallmarks of human cancers and are characterized by global DNA hypomethylation of repetitive elements and non-CpG rich regions concomitant with locus-specific DNA hypermethylation. DNA methylation changes may result in altered gene expression profiles, most notably the silencing of tumor suppressors, microRNAs, endogenous retorviruses and tumor antigens due to promoter DNA...

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PMID: 28358281
DOI: 10.1080/15592294.2017.1311434

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