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Shared IGHV1-69-encoded neutralizing antibodies contribute to the emergence of L452R substitution in SARS-CoV-2 variants

26 Oct 2022

Abstract excerpt

SARS-CoV-2 variants continue to emerge facing established herd immunity. L452R, previously featured in the Delta variant, quickly emerged in Omicron subvariants, including BA.4/BA.5, implying a continued selection pressure on this residue. The underlying links between spike mutations and their selective pressures remain incompletely understood. Here, by analyzing 221 structurally characterized antibodies, we...

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PMID: 36288106
DOI: 10.1080/22221751.2022.2140611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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