Article

Convergent IGHV3-53/3-66 antibodies elicited by Omicron BA.1 infection broadly neutralize emerging SARS-CoV-2 variants

2026-08-17

Abstract excerpt

<h4>Summary</h4> Natural SARS-CoV-2 infections or vaccinations induce neutralizing antibodies (nAbs) offer protection from severe disease. The shared use of IGHV3-53/3-66 genes makes this class of monoclonal antibodies (mAbs) a public clonotype and is well established, but the evolution and structural basis of how these public antibodies maintain broad binding and acquire potent neutralizing activity is not comp...

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Literature Corpus work: d0581f62-e4f2-5473-b5d3-6793a69167c9
DOI: 10.64898/2026.08.15.745004

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