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Article

The histone variant macroH2A is an epigenetic regulator of key developmental genes.

Nature structural & molecular biology - 1 Oct 2009

Buschbeck Marcus, Uribesalgo Iris, Wibowo Indra, Rué Pau, Martin David, Gutierrez Arantxa, Morey Lluís, Guigó Roderic, López-Schier Hernán, Di Croce Luciano

Abstract excerpt

The histone variants macroH2A1 and macroH2A2 are associated with X chromosome inactivation in female mammals. However, the physiological function of macroH2A proteins on autosomes is poorly understood. Microarray-based analysis in human male pluripotent cells uncovered occupancy of both macroH2A variants at many genes encoding key regulators of development and cell fate decisions. On these genes, the presence of...

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PMID: 19734898
DOI: 10.1038/nsmb.1665

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