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Integrative CUT&Tag/RNA-Seq analysis of histone variant macroH2A1-dependent orchestration of human iPSCs reprogramming

2022-10-03

Abstract excerpt

<h4>ABSTRACT</h4> Human-induced pluripotent stem cells (iPSCs) can be derived from adult stem cells by forced expression of defined transcription factors. This paves the way for autologous iPSC-derived therapies, which, however, are not yet considered safe. Moreover, reprogramming of somatic cells into iPSCs is an inefficient process, in the range of 0.1%–1%. The epigenetic mechanisms implicated in iPSCs reprogra...

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Literature Corpus work
6fa4c3f6-2472-51f1-b9e9-53ef600a0c6b
DOI
10.1101/2022.09.30.510248
Open publication

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Integrative CUT&Tag/RNA-Seq analysis of histone variant macroH2A1-dependent orchestration of human iPSCs reprogrammingDOI 10.1101/2022.09.30.510248
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