Article
Macrohistone variants preserve cell identity by preventing the gain of H3K4me2 during reprogramming to pluripotency.
Cell reports - 25 Apr 2013
Barrero María J, Sese Borja, Kuebler Bernd, Bilic Josipa, Boue Stephanie, Martí Mercè, Izpisua Belmonte Juan Carlos
Abstract excerpt
Transcription-factor-induced reprogramming of somatic cells to pluripotency is a very inefficient process, probably due to the existence of important epigenetic barriers that are imposed during differentiation and that contribute to preserving cell identity. In an effort to decipher the molecular nature of these barriers, we followed a genome-wide approach, in which we identified macrohistone variants (macroH2A)...
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