Article
Comparison of HLA allelic imputation programs.
PloS one - 1 Jan 2017
Karnes Jason H, Shaffer Christian M, Bastarache Lisa, Gaudieri Silvana, Glazer Andrew M, Steiner Heidi E, Mosley Jonathan D, Mallal Simon, Denny Joshua C, Phillips Elizabeth J, Roden Dan M
Abstract excerpt
Imputation of human leukocyte antigen (HLA) alleles from SNP-level data is attractive due to importance of HLA alleles in human disease, widespread availability of genome-wide association study (GWAS) data, and expertise required for HLA sequencing. However, comprehensive evaluations of HLA imputations programs are limited. We compared HLA imputation results of HIBAG, SNP2HLA, and HLA*IMP:02 to sequenced HLA...
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