Article

Divergent Excitability of GABAergic Neurons Derived from Bipolar Disorder Patients Shapes Energy Shifts of Network Dynamics, possibly mimicking mania and depression

2025-08-28

Abstract excerpt

<h4>ABSTRACT</h4> Bipolar disorder (BD) is characterized by fluctuating mood states, yet the cellular and circuit-level mechanisms distinguishing lithium-responsive (LR) from non-responsive (NR) patients remain elusive. We derived dentate gyrus granule neurons and GABAergic interneurons from induced pluripotent stem cells (iPSCs) of BD patients stratified by lithium response, and from healthy controls. Using patc...

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Literature Corpus work: 55613d32-f9b7-574b-953e-fa5822f69c64
DOI: 10.1101/2025.08.28.672780

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