Article

From iPSCs to NPCs to cortical neurons: bioenergetic, neuronal, and calcium signaling phenotypes in bipolar disorder with and without familial mitochondrial disease

2025-12-22

Abstract excerpt

<h4>Background</h4> Psychiatric disorders frequently accompany primary mitochondrial diseases (PMDs), implicating mitochondrial dysfunction as a shared biological substrate for psychiatric vulnerability. To determine how familial mitochondrial risk influences neuronal development in bipolar disorder (BD), we generated induced pluripotent stem cells (iPSCs), neural progenitor cells (NPCs), and cortical neurons (CN...

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Literature Corpus work: dd965c0b-1d19-5af9-b640-b3e4c2f86fb4
DOI: 10.64898/2025.12.19.695603

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