Article

Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response

2020-12-15

Abstract excerpt

Bipolar disorder (BD) is a neuropsychiatric disorder with genetic risk factors defined by recurrent episodes of mania/hypomania, depression and circadian rhythm abnormalities. While lithium is an effective drug for BD, 30-40% of patients fail to respond adequately to treatment. Previous work has demonstrated that lithium affects the expression of “clock genes” and that lithium responders (Li-R) can be distinguishe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 410c3055-25bf-58fd-9902-2dcade26f9ec
DOI: 10.1101/2020.12.14.422616

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Circadian rhythms in bipolar disorder patient-derived neurons predict lithium responseDOI 10.1101/2020.12.14.422616Read

Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder.Semantic proximity Read

Lithium response in bipolar disorders and core clock genes expressionSemantic proximity Read

Differential contributions of circadian clock genes to cell survival in bipolar disorder patient derived neuronal progenitor cells distinguishes lithium responders and non-respondersSemantic proximity Read

Molecular signatures of hyperexcitability and lithium responsiveness in bipolar disorder patient neurons provide alternative therapeutic strategiesSemantic proximity Read

Divergent Excitability of GABAergic Neurons Derived from Bipolar Disorder Patients Shapes Energy Shifts of Network Dynamics, possibly mimicking mania and depressionSemantic proximity Read

Altered Protein Phosphorylation in a Novel Midbrain Organoid Model for Bipolar DisorderSemantic proximity Read

Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patientsSemantic proximity Read

Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca2+ entry and accelerated differentiationSemantic proximity Read

Contributions of circadian clock genes to cell survival in fibroblast models of lithium-responsive bipolar disorder.Semantic proximity Read

Modulation of Neuronal Excitability and Plasticity by BHLHE41 Conveys Lithium Non-ResponsivenessSemantic proximity Read

[Circadian markers and genes in bipolar disorder].Semantic proximity Read

Exploring lithium’s transcriptional mechanisms of action in bipolar disorder: a multi-step studySemantic proximity Read