Article
Identification of leukemia stem cell subsets with distinct transcriptional, epigenetic and functional properties
21 Aug 2024
Abstract excerpt
The leukemia stem cell (LSC) compartment is a complex reservoir fueling disease progression in acute myeloid leukemia (AML). The existence of heterogeneity within this compartment is well documented but prior studies have focused on genetic heterogeneity without being able to address functional heterogeneity. Understanding this heterogeneity is critical for the informed design of therapies targeting LSC, but has...
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