Back to search

Article

Identification of leukemia stem cell subsets with distinct transcriptional, epigenetic and functional properties

2024-02-12

Abstract excerpt

The leukemia stem cell (LSC) compartment is a complex reservoir fueling disease progression in acute myeloid leukemia (AML). The existence of heterogeneity within this compartment is well documented but prior studies have focused on genetic heterogeneity without being able to address functional heterogeneity. Understanding this heterogeneity is critical for the informed design of therapies targeting LSC, but has b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f84172c2-d74c-52f9-82ac-662861fb6401
DOI
10.1101/2024.02.09.579319
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Identification of leukemia stem cell subsets with distinct transcriptional, epigenetic and functional propertiesDOI 10.1101/2024.02.09.579319
Identification of leukemia stem cell subsets with distinct transcriptional, epigenetic and functional propertiesSemantic proximity
Biology and relevance of human acute myeloid leukemia stem cellsSemantic proximity
Acute Myeloid Leukemia Stem Cells: The Challenges of Phenotypic HeterogeneitySemantic proximity
A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genomeSemantic proximity
Single cell multi-omics enables high-resolution identification and functional purification of human acute myeloid leukemia stem cellsSemantic proximity
Resolving leukemic stem cell heterogeneity and plasticity with single-cell multiomicsSemantic proximity
How to drug a leukemic stem cell: deciphering heterogeneity for better specificitySemantic proximity
Recent advances in acute myeloid leukemia stem cell biologySemantic proximity
Single-cell analysis of acute lymphoblastic and lineage-ambiguous leukemia: approaches and molecular insightsSemantic proximity
Leukemia stem cellsSemantic proximity
Acute myeloid leukemia stem cells: seek and destroySemantic proximity
Therapeutic targeting of acute myeloid leukemia stem cellsSemantic proximity
Select a neighboring publication to make it the new centre.