Article

Lineage plasticity in SCLC generates non-neuroendocrine cells primed for vasculogenic mimicry

2022-10-21

Abstract excerpt

<h4>Introduction</h4> Vasculogenic mimicry (VM), the process of tumor cell trans-differentiation to endow endothelial-like characteristics supporting de novo vessel formation, is associated with poor prognosis in several tumor types, including small cell lung cancer (SCLC). In genetically engineered mouse models (GEMMs) of SCLC, NOTCH and MYC co-operate to drive a neuroendocrine (NE) to non-NE phenotypic switch...

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Literature Corpus work: 552aa848-ad24-5a4b-84ee-865bbf83ad85
DOI: 10.1101/2022.10.21.512986

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