Article

Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform

2021-12-07

Abstract excerpt

<h4>ABSTRACT</h4> Lung cancer is the leading cause of cancer-related death worldwide. Lung adenocarcinoma (LUAD), the most common histological subtype, accounts for 40% of all cases. While genetically engineered mouse models (GEMMs) recapitulate the histological progression and transcriptional evolution of human LUAD, they are slow and technically demanding. In contrast, cell line transplant models are fast and f...

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Literature Corpus work: d3f55048-f20c-5533-8e11-0793c671fd78
DOI: 10.1101/2021.12.07.471632

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