Article
Vasculogenic mimicry in small cell lung cancer.
Nature communications - 9 Nov 2016
Williamson Stuart C, Metcalf Robert L, Trapani Francesca, Mohan Sumitra, Antonello Jenny, Abbott Benjamin, Leong Hui Sun, Chester Christopher P E, Simms Nicole, Polanski Radoslaw, Nonaka Daisuke, Priest Lynsey, Fusi Alberto, Carlsson Fredrika, Carlsson Anders, Hendrix Mary J C, Seftor Richard E B, Seftor Elisabeth A, Rothwell Dominic G, Hughes Andrew, Hicks James, Miller Crispin, Kuhn Peter, Brady Ged, Simpson Kathryn L, Blackhall Fiona H, Dive Caroline
Abstract excerpt
Small cell lung cancer (SCLC) is characterized by prevalent circulating tumour cells (CTCs), early metastasis and poor prognosis. We show that SCLC patients (37/38) have rare CTC subpopulations co-expressing vascular endothelial-cadherin (VE-cadherin) and cytokeratins consistent with vasculogenic mimicry (VM), a process whereby tumour cells form 'endothelial-like' vessels. Single-cell genomic analysis reveals...
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