Article

Extracellular vesicles modulate integrin signaling and subcellular energetics to promote pulmonary lymphangioleiomyomatosis metastasis

2025-03-20

Abstract excerpt

<title>Abstract</title> <p> Pulmonary lymphangioleiomyomatosis (LAM) is metastatic sarcoma but mechanisms of LAM metastasis are unknown. Extracellular vesicles (EV) regulate cancer metastasis but their roles in LAM have not yet been thoroughly investigated. Here, we report the discovery of distinct LAM-EV subtypes derived from primary tumor or metastasizing LAM cells that promote LAM metastasis through ITGα6/β1-...

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Literature Corpus work: cf8d468d-b7b3-563b-a9b0-b3aa6dd27b0d
DOI: 10.21203/rs.3.rs-5390547/v1

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