Article

Delayed localization of A-type lamins to the rupture sites in Hutchinson–Gilford progeria syndrome

2023-09-02

Abstract excerpt

The nuclear lamina (NL) lines the nuclear envelope (NE) to maintain nuclear structure in metazoan cells. The major NL components, the nuclear lamins contribute to the protection against NE rupture induced by mechanical stress. Lamin A (LA) and a short form of the splicing variant lamin C (LC) are diffused from the nucleoplasm to sites of NE rupture in immortalized mouse embryonic fibroblasts (MEFs). LA localizatio...

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Literature Corpus work: bd80f64d-b2d9-5076-8c0b-dac78a0e8d0a
DOI: 10.1101/2023.09.02.555826

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