Article

Microdynamics of lamin A Ig-fold domain regulates higher order assembly of the protein

2022-01-28

Abstract excerpt

Lamins maintain the shape and rigidity of the nucleus in the form of a proteinaceous scaffold underneath the inner nuclear membrane (INM) and provide anchorage to chromatin and other nuclear proteins. Mutations in the human LMNA gene encoding lamin A/C cause about 16 different diseases with distinct phenotypes collectively termed as laminopathies which affect primarily the muscle tissues as well as adipose tissues...

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Literature Corpus work: fc92de54-fec6-5520-bd6c-88e21e1555b8
DOI: 10.1101/2022.01.27.478013

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