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Article

Nuclear stiffening and chromatin softening with progerin expression leads to an attenuated nuclear response to force.

Soft matter - 28 Aug 2015

Booth Elizabeth A, Spagnol Stephen T, Alcoser Turi A, Dahl Kris Noel

Abstract excerpt

Progerin is a mutant form of the nucleoskeletal protein lamin A, and its expression results in the rare premature aging disorder Hutchinson-Gilford progeria syndrome (HGPS). Patients with HGPS demonstrate several characteristic signs of aging including cardiovascular and skeletal dysfunction. Cells from HGPS patients show several nuclear abnormalities including aberrant morphology, nuclear stiffening and loss of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26171741
DOI: 10.1039/c5sm00521c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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