Article
Dysfunctional connections between the nucleus and the actin and microtubule networks in laminopathic models.
Biophysical journal - 1 Dec 2008
Hale Christopher M, Shrestha Arun L, Khatau Shyam B, Stewart-Hutchinson P J, Hernandez Lidia, Stewart Colin L, Hodzic Didier, Wirtz Denis
Abstract excerpt
Laminopathies encompass a wide array of human diseases associated to scattered mutations along LMNA, a single gene encoding A-type lamins. How such genetic alterations translate to cellular defects and generate such diverse disease phenotypes remains enigmatic. Recent work has identified nuclear envelope proteins--emerin and the linker of the nucleoskeleton and cytoskeleton (LINC) complex--which connect the...
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