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Article

Lysosomal Storage Diseases-Regulating Neurodegeneration

1 Jan 2015

Abstract excerpt

Autophagy is a complex pathway regulated by numerous signaling events that recycles macromolecules and can be perturbed in lysosomal storage diseases (LSDs). The concept of LSDs, which are characterized by aberrant, excessive storage of cellular material in lysosomes, developed following the discovery of an enzyme deficiency as the cause of Pompe disease in 1963. Great strides have since been made in better...

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PMID: 27081317
DOI: 10.4137/jen.s25475

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