Article

Tagless LysoIP method for molecular profiling of lysosomal content in clinical samples

2024-05-19

Abstract excerpt

Lysosomes are implicated in a wide spectrum of human diseases including monogenic lysosomal storage disorders (LSDs), age-associated neurodegeneration and cancer. Profiling lysosomal content using tag-based lysosomal immunoprecipitation (LysoTagIP) in cell and animal models allowed major discoveries in the field, however studying lysosomal dysfunction in human patients remains challenging. Here, we report the deve...

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Literature Corpus work: 2bac0391-2927-583e-bea7-5326dc57a897
DOI: 10.1101/2024.05.17.594681

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