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Tagless LysoIP for immunoaffinity enrichment of native lysosomes from clinical samples

26 Dec 2024

Abstract excerpt

Lysosomes are implicated in a wide spectrum of human diseases, including monogenic lysosomal storage disorders (LSDs), age-associated neurodegeneration, and cancer. Profiling lysosomal content using tag-based lysosomal immunoprecipitation (LysoTagIP) in cell and animal models has substantially moved the field forward, but studying lysosomal dysfunction in patients remains challenging. Here, we report the...

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PMID: 39724071
DOI: 10.1172/jci183592

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