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Multi-omics analysis reveals the panoramic picture of TOP2A in pan-cancer

19 Feb 2025

Abstract excerpt

Topoisomerases are critical nuclear enzymes that resolve DNA topological challenges during genetic processes. However, there is currently a lack of comprehensive multi-omics analysis of TOP2A from a pan-cancer perspective, despite its significance. A multiomics analysis was conducted to investigate TOP2A across various cancer types. This study involved the integration of over 10,000 multidimensional genomic...

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Cancer Genomics and Diagnostics
DNA Repair Mechanisms
Lung Cancer Treatments and Mutations

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39972040
DOI: 10.1038/s41598-025-85929-9

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