Article

Recurrent mutations in topoisomerase 2a cause a novel mutator phenotype in human cancers

2020-05-25

Abstract excerpt

Topoisomerases are essential for genome stability. Here, we link the p.K743N mutation in topoisomerase TOP2A to a previously undescribed mutator phenotype in human cancers. This phenotype primarily generates a distinctive pattern of duplications of 2 to 4 base pairs and deletions of 6 to 8 base pairs, which we call ID_TOP2A. All tumors carrying the TOP2A p.K743N mutation showed ID_TOP2A, which was absent in all of...

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Identifiers and source

Literature Corpus work: 4716c782-1e7e-56af-bbed-ced8dfab002d
DOI: 10.1101/2020.05.22.111666

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