Article

The novel, recurrent mutation in the <i>TOP2A</i> gene results in the enhanced topoisomerase activity and transcription deregulation in glioblastoma

2020-06-18

Abstract excerpt

<h4>Background</h4> High grade gliomas (HGGs) are aggressive, primary brain tumors with poor clinical outcomes. We aim to better understand glioma pathobiology and find potential therapeutic susceptibilities. <h4>Methods</h4> We designed a custom panel of 664 cancer- and epigenetics-related genes, and employed targeted next generation sequencing to study the genomic landscape of somatic and germline variants in...

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Literature Corpus work: 2490df9a-99f6-5dbb-98ab-0d687fbd900a
DOI: 10.1101/2020.06.17.158477

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