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Article

Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma.

Nature communications - 10 Aug 2021

Yamagishi Makoto, Kubokawa Miyuki, Kuze Yuta, Suzuki Ayako, Yokomizo Akari, Kobayashi Seiichiro, Nakashima Makoto, Makiyama Junya, Iwanaga Masako, Fukuda Takahiro, Watanabe Toshiki, Suzuki Yutaka, Uchimaru Kaoru

Abstract excerpt

Subclonal genetic heterogeneity and their diverse gene expression impose serious problems in understanding the behavior of cancers and contemplating therapeutic strategies. Here we develop and utilize a capture-based sequencing panel, which covers host hotspot genes and the full-length genome of human T-cell leukemia virus type-1 (HTLV-1), to investigate the clonal architecture of adult T-cell leukemia-lymphoma...

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Identifiers

PMID: 34376672
DOI: 10.1038/s41467-021-25101-9
PMCID: PMC8355240

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