Single-cell RNA-seq reveals developmental plasticity with coexisting oncogenic states and immune evasion programs in ETP-ALL.

doi:10.1182/blood.2019004547

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Article

Single-cell RNA-seq reveals developmental plasticity with coexisting oncogenic states and immune evasion programs in ETP-ALL.

Blood - 6 May 2021

Anand Praveen, Guillaumet-Adkins Amy, Dimitrova Valeriya, Yun Huiyoung, Drier Yotam, Sotudeh Noori, Rogers Anna, Ouseph Madhu M, Nair Monica, Potdar Sayalee, Isenhart Randi, Kloeber Jake A, Vijaykumar Tushara, Niu Leili, Vincent Tiffaney, Guo Guangwu, Frede Julia, Harris Marian H, Place Andrew E, Silverman Lewis B, Teachey David T, Lane Andrew A, DeAngelo Daniel J, Aster Jon C, Bernstein Bradley E, Lohr Jens G, Knoechel Birgit

Abstract excerpt

Lineage plasticity and stemness have been invoked as causes of therapy resistance in cancer, because these flexible states allow cancer cells to dedifferentiate and alter their dependencies. We investigated such resistance mechanisms in relapsed/refractory early T-cell progenitor acute lymphoblastic leukemia (ETP-ALL) carrying activating NOTCH1 mutations via full-length single-cell RNA sequencing (scRNA-seq) of...

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PMID: 33227818
DOI: 10.1182/blood.2019004547
PMCID: PMC8109012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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